Impact of Healthcare on Stock Market Volatility and Its Predictive Solution Using Improved Neural Network.

The unprecedented Corona Virus Disease (COVID-19) pandemic has put the world in peril and shifted global landscape in unanticipated ways. The SARSCoV2 virus, which caused the COVID-19 outbreak, first appeared in Wuhan, Hubei Province, China, in December 2019 and quickly spread around the world. This pandemic is not only a global health crisis, but it has caused the major global economic depression. As soon as the virus spread, stock market prices plummeted and volatility increased. Predicting the market during this outbreak has been of substantial importance and is the primary motivation to carry out this work. Given the nonlinearity and dynamic nature of stock data, the prediction of stock market is a challenging task. The machine learning models have proven to be a good choice for the development of effective and efficient prediction systems. In recent years, the application of hyperparameter optimization techniques for the development of highly accurate models has increased significantly. In this study, a customized neural network model is proposed and the power of hyperparameter optimization in modelling stock index prices is explored. A novel dataset is generated using nine standard technical indicators and COVID-19 data. In addition, the primary focus is on the importance of selection of optimal features and their preprocessing. The utilization of multiple feature ranking techniques combined with extensive hyperparameter optimization procedures is comprehensive for the prediction of stock index prices. Moreover, the model is evaluated by comparing it with other models, and results indicate that the proposed model outperforms other models. Given the detailed design methodology, preprocessing, exploratory feature analysis, and hyperparameter optimization procedures, this work gives a significant contribution to stock analysis research community during this pandemic.

SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?

The global COVID-19 pandemic continues due to emerging Severe Acute Respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC). Here, we performed comprehensive analysis of in-house sequenced SARS-CoV-2 genome mutations dynamics in the patients infected with the VOCs - Delta and Omicron, within Recovered and Mortality patients. Statistical analysis highlighted significant mutations - T4685A, N4992N, and G5063S in RdRp; T19R in NTD spike; K444N and N532H in RBD spike, associated with Delta mortality. Mutations, T19I in NTD spike, Q493R and N440K in the RBD spike were significantly associated with Omicron mortality. We performed molecular docking for possible effect of significant mutations on the binding of Remdesivir. We found that Remdesivir showed less binding efficacy with the mutant Spike protein of both Delta and Omicron mortality compared to recovered patients. This indicates that mortality associated mutations could have a modulatory effect on drug binding which could be associated with disease outcome.

Impact of Healthcare on Stock Market Volatility and Its Predictive Solution Using Improved Neural Network

The unprecedented Corona Virus Disease (COVID-19) pandemic has put the world in peril and shifted global landscape in unanticipated ways. The SARSCoV2 virus, which caused the COVID-19 outbreak, first appeared in Wuhan, Hubei Province, China, in December 2019 and quickly spread around the world. This pandemic is not only a global health crisis, but it has caused the major global economic depression. As soon as the virus spread, stock market prices plummeted and volatility increased. Predicting the market during this outbreak has been of substantial importance and is the primary motivation to carry out this work. Given the nonlinearity and dynamic nature of stock data, the prediction of stock market is a challenging task. The machine learning models have proven to be a good choice for the development of effective and efficient prediction systems. In recent years, the application of hyperparameter optimization techniques for the development of highly accurate models has increased significantly. In this study, a customized neural network model is proposed and the power of hyperparameter optimization in modelling stock index prices is explored. A novel dataset is generated using nine standard technical indicators and COVID-19 data. In addition, the primary focus is on the importance of selection of optimal features and their preprocessing. The utilization of multiple feature ranking techniques combined with extensive hyperparameter optimization procedures is comprehensive for the prediction of stock index prices. Moreover, the model is evaluated by comparing it with other models, and results indicate that the proposed model outperforms other models. Given the detailed design methodology, preprocessing, exploratory feature analysis, and hyperparameter optimization procedures, this work gives a significant contribution to stock analysis research community during this pandemic.

The debate around the access to vaccine and licensing amidst second wave of COVID-19 in India.

The guardian of global health signified a "global response" to contain COVID 19 utilising the platform of World Health Organization when the novel virus strain was spreading. The nature of "waves," that is, variable epidemiological patterns and peaks in trajectory, have been inconsistent and myriad in different regions and countries. Many researchers and scholars have deliberated on the possible ways forward to curb or mitigate the effects of the virus; and one such means is through universal vaccination. Hence, this article explores the positions to achieve that goal by looking at the licensing aspect and IP waiver debate and suggests a fine-tuning which balances all the interests, amidst the second wave in India.

COVID-19: Challenges and its Technological Solutions using IoT.

COVID-19 is a global pandemic that has affected many countries in a short span of time. People worldwide are susceptible to this deadly disease. To control the prevailing havoc of coronavirus, researchers are adopting techniques like plasma therapy, proning, medicines, etc. To stop the rapid spread of COVID-19, contact tracing is one of the important ways to check the infected people. This paper explains the various challenges people and health practitioners are facing due to COVID-19. In this paper, various ways with which the impact of COVID-19 can be controlled using IoT technology have been discussed. A six-layer architecture of IoT solutions for containing the deadly COVID-19 has been proposed. In addition to this, the role of machine learning techniques for diagnosing COVID-19 has been discussed in this paper, and a quick explanation of the unmanned aerial vehicle (UAVs) applications for contact tracing has also been specified. From the study conducted, it is evident that IoT solutions can be used in various ways for restricting the impact of COVID-19. Furthermore, IoT can be used in the healthcare sector to assure people's safety and good health with minimal costs.